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Table 6 Simple TMHs are less similar than complex TMHs to TMHs from multi-pass proteins in ExpAll

From: Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Residues P values for χ2 Bahadur slopes for χ2
Simple-vs-complex Simple-vs-multi Complex-vs-multi Simple-vs-complex Simple-vs-multi Complex-vs-multi
 R 5.10E-06 2.98E-01 5.10E-06 9.17E-03 1.61E-03 6.23E-05
 K 2.35E-03 1.85E-01 2.35E-03 4.81E-03 3.88E-03 9.78E-05
 D 2.61E-08 1.84E-01 2.61E-08 4.15E-02 7.90E-03 1.41E-04
 E 2.38E-10 2.04E-01 2.38E-10 3.88E-02 7.08E-03 1.22E-04
 Y 3.03E-01 3.11E-01 3.03E-01 2.01E-03 2.49E-03 5.51E-05
 W 4.21E-03 4.29E-01 4.21E-03 1.11E-02 4.76E-03 6.46E-05
 L 3.79E-01 3.04E-01 3.79E-01 2.28E-04 4.66E-04 1.50E-05
 C 3.87E-01 2.52E-01 3.87E-01 1.75E-03 3.28E-03 1.48E-04
 R + K 7.16E-04 2.52E-01 7.16E-04 2.80E-03 1.28E-03 3.76E-05
 D + E 3.58E-05 2.94E-01 3.58E-05 1.03E-02 1.94E-03 4.90E-05
  P values for Kolmogorov-Smirnov Bahadur slopes for Kolmogorov-Smirnov
  Simple-vs-complex Simple-vs-multi Complex-vs-multi Simple-vs-complex Simple-vs-multi Complex-vs-multi
 R 3.61E-01 4.31E-02 3.61E-01 7.66E-04 7.79E-03 1.62E-04
 K 4.31E-02 8.93E-01 4.31E-02 2.49E-03 1.05E-02 6.57E-06
 D 1.39E-01 2.18E-03 1.39E-01 4.68E-03 3.61E-02 5.10E-04
 E 5.31E-01 1.33E-04 5.31E-01 1.11E-03 2.81E-02 6.87E-04
 Y 2.31E-01 9.06E-04 2.31E-01 2.47E-03 6.26E-03 3.30E-04
 W 5.31E-01 4.98E-03 5.31E-01 1.29E-03 1.13E-02 4.04E-04
 L 2.31E-01 2.31E-01 2.31E-01 3.45E-04 2.12E-03 1.85E-05
 C 5.31E-01 3.61E-01 5.31E-01 1.16E-03 8.91E-04 1.09E-04
 R + K 1.39E-01 2.31E-01 1.39E-01 7.61E-04 4.82E-03 4.00E-05
 D + E 1.39E-01 9.06E-04 1.39E-01 1.99E-03 1.41E-02 2.80E-04
  P values for Kruskal-Wallis Bahadur slopes for Kruskal-Wallis
  Simple-vs-complex Simple-vs-multi Complex-vs-multi Simple-vs-complex Simple-vs-multi Complex-vs-multi
 R 4.37E-01 3.92E-01 4.37E-01 6.24E-04 2.52E-03 4.82E-05
 K 3.83E-01 6.93E-01 3.83E-01 7.62E-04 2.88E-03 2.13E-05
 D 4.49E-01 1.81E-01 4.49E-01 1.90E-03 1.06E-02 1.42E-04
 E 7.64E-01 1.94E-01 7.64E-01 4.71E-04 9.05E-03 1.26E-04
 Y 8.32E-01 3.36E-01 8.32E-01 3.09E-04 9.63E-04 5.15E-05
 W 7.25E-01 1.36E-01 7.25E-01 6.53E-04 5.44E-03 1.52E-04
 L 7.15E-01 7.95E-01 7.15E-01 7.90E-05 3.41E-04 2.90E-06
 C 8.47E-01 9.54E-01 8.47E-01 3.05E-04 4.26E-05 5.06E-06
 R + K 2.89E-01 5.13E-01 2.89E-01 4.79E-04 1.41E-03 1.82E-05
 D + E 4.94E-01 2.07E-01 4.94E-01 7.11E-04 4.14E-03 6.29E-05
  1. As in Table 5, the statistical results were gathered by comparing complex single-pass TMHs, simple TMHs from single-pass proteins and TMHs from multi-pass proteins; however, in this case only ExpAll is used. The abundance of different residues at each position when using the centrally aligned TMH approach was compared with several statistical tests (Kolmogorov-Smirnov, Kruskal-Wallis and the χ2 statistical tests) and the Bahadur slope values of those results
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