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Fig. 4 | BMC Biology

Fig. 4

From: Distinct unfolded protein responses mitigate or mediate effects of nonlethal deprivation of C. elegans sleep in different tissues

Fig. 4

Mitigating mitochondrial (but not ER) stress is required for maintaining normal post-deprivation pumping rates. a Box plots of average pumping rates for control (i.e., stimulated outside of lethargus) and deprived animals obtained with the optical tracking method. Loss of DAF-16 or mec-10 expressing neurons confers a broad defect in stress responses or the loss of gentle mechanosensation, respectively. b Average pumping rates of animals deficient in the UPRmt (left) and the UPRER (right). Horizontal lines, boxes, and bars depict medians, 1st and 3rd quartiles, and 5th and 95th percentiles, respectively. Sample sizes are noted in parentheses; asterisks and double asterisks denote significant differences (p < 0.05 and p < 0.01, respectively)

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