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Fig. 5. | BMC Biology

Fig. 5.

From: Biological function in the twilight zone of sequence conservation

Fig. 5.

Protein-coding sequence turns over very slowly but is a minority of all constrained sequence; functional non-coding sequence turns over rapidly and contributes most to constrained sequence. Circle areas reflect proportions of annotations that are constrained (~8% for the mammalian genome); annotations are not mutually exclusive. Protein-coding sequence half-life is approximately the age of bilateral animals, and the half-lives of functional non-coding sequence are approximately the age of the radiation of placental mammals [91,92,93]. Further details of the data and the evolutionary model are provided in [44]

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