Fig. 8
From: SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis
A model illustrating that SKIP is required for the pre-mRNA splicing of SEF to activate the expression of FLC and MAFs and delay flowering in Arabidopsis. In this model, SKIP, a spliceosome component, regulates the pre-mRNA splicing of SEF, which is integrated into the ATP-dependent SWR1-C. The SWR1-C regulates the substitution of H2A by H2A.Z at FLC and MAF chromatin, leading to increased FLC/MAF expression and delayed flowering in Arabidopsis. The intron 1 retention alternative splicing form of SEF does not function as SEF mature mRNA, which may be decayed through the nonsense-mediated mRNA decay (NMD) or the mechanisms unknown