Fig. 1.

Selective sweeps and background selection. Maynard Smith and Haigh [79] showed that as an advantageous mutation rises in frequency it drags with it linked neutral polymorphisms. With increasing genetic distance from the selected site, the effect is reduced, resulting in troughs in genetic diversity in surrounding regions. a Hard/classic sweeps - the most well-studied model of sweeps. A new advantageous mutation rapidly increases in frequency to eventual fixation. As it sweeps, the adaptive allele carries with it a portion of the haplotype on which it arose, reducing levels of neutral diversity in the surrounding area [27, 79]. b-c Soft sweeps - a neutral allele segregating in a population may become favoured (due, for example, to a change in the environment). b The segregating allele may be associated with multiple haplotypes, and as it rises in frequency, so do the multiple haplotypes. c A similar process, also termed a soft sweep, can occur if an advantageous mutation arises by multiple, distinct mutation events. See [66] for a thorough review on soft sweep models. d Incomplete/partial sweeps - If an advantageous allele increases in frequency, but does not reach fixation, there will still be some loss of linked neutral diversity. In this review, we use the term incomplete sweeps to describe sweeps that are polymorphic at the time of sampling, but may (or may not) eventually reach fixation a. The term partial sweep describes the situation wherein a sweeping allele becomes effectively neutral at a certain frequency in its trajectory d. The magnitude of both processes’ effects on linked neutral diversity depends on the frequency reached by the sweeping allele when selection is ‘turned off’ or on the time of sampling [33]. Partial sweeps may be common in cases of adaptation involving selection on quantitative traits [67]. e Background selection - as natural selection purges deleterious mutations, neutral alleles linked to the selected locus are also lost. The process of background selection is qualitatively similar to recurrent selective sweeps, since both processes reduce local genetic diversity [80] and skew the SFS towards rare variants [81, 82]. Models of background selection envisage a neutral site linked to many functional sites at different distances, such that the effects of selection at many sites accumulate to reduce diversity [83, 84]. Blue circles represent neutral alleles, red, yellow and orange circles represent advantageous alleles, and red squares represent deleterious alleles