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Fig. 2 | BMC Biology

Fig. 2

From: Lipid metabolism fattens up hedgehog signaling

Fig. 2

Lipid synthesis pathways. Cholesterol (brown), phospholipids (blue), and fatty acids (green) are synthesized from acetyl-CoA via a series of intermediate metabolites. Oxysterols are enzymatically produced from 7-dehydrocholesterol (7DHC) and cholesterol by Cytochrome P450 (CYT P450) enzyme family members, and are also generated non-enzymatically (not shown). Enzymes described in the text are shown in red. Both 7DHC and 7-dehydrodesmosterol are substrates for 7-dehydrocholesterol reductase (DHCR7). Fatty acids contribute to the synthesis of phospholipids from glycerol-3-phosphate. Multiple enzyme reactions not shown are represented by double arrows. TG triclyceride, CDP-DAG cytidine diphosphate di-acyl glycerol, PI phosphatidylinositol, HMG-CoA 3-hydroxy-3-methylglutaryl coenzyme A, HMGCR HMG-CoA reductase, PIP phosphatidylinositol phosphate, PC phosphatidyl-choline, PE phosphatidyl-ethanolamine, PS phosphatidyl-serine

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