Fig. 9From: RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitinationRNA is important for TRIM25’s E3 ubiquitin ligase function. a Proposed model whereby ubiquitin ligase activity of TRIM25 is substantially enhanced by using RNA as a scaffold. b Proposed model whereby binding of TRIM25 to RNA could enhance its ubiquitin ligase activity by allosteric changeBack to article page