Fig. 6

Proteomic analysis of Pparα ^-/- retinas. a Heatmap representation of lipid transporters, fatty acid oxidation, glycolytic, citric acid cycle, electron transport chain, and antioxidant enzymes measured by proteomic analysis. Please refer to Additional file 7: Figure S7 for full analysis. b Lipid transporters ATP binding cassette subfamily d member 3 (Abcd3), carnitine acetyl-transferase (Crat), and carnitine o-octanyltransferase (Crot) were unchanged in 40-week-old Pparα ^-/- retinas relative to age-matched wild-type (WT). Carnitine palmitoyltransferase 1a (Cpt1a), fatty acid binding protein (Fabp3), and solute carrier family 25 member 20 (Slc25a20) were decreased in Pparα ^-/- retinas. c Glycolytic enzymes hexokinase 1 (Hk1), lactate dehydrogenase-brain (Ldhb), phosphofructokinase muscle (Pfkm), phosphoglycerate mutase 2 (Pgam2), and triosephosphate isomerase 1 (Tpi) were increased in Pparα ^-/- retinas. d Antioxidant enzymes glutathione s-transferase alpha-3 (Gsta3), glutathione s-transferase mu 1 (Gstm1), peroxidase-5 and -6 (Prdx5, Prdx6), and thioredoxin reductase 1 (Txnrd1) were increased in Pparα ^-/- retinas (WT, n = 6; Pparα ^-/-, n = 4). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, unpaired two-tailed Student’s t test