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Fig. 4 | BMC Biology

Fig. 4

From: Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell

Fig. 4

scT&R-seq analysis of heterogeneity in pluripotency gene expression of hESCs. a Distribution of PluriNet score. Gene set for PluriNet score was generated from study in GEO (Chu et al. [45]). b Correlation between the averaged PluriNet score and telomere length (T/R ratio). hESCs were divided into three groups by Log (PluriNet score) and Log (T/R ratio), Group_1 (Log (T/R ratio) > 0; Log (PluriNet score) > 3.0), Group_2 (Log (T/R ratio) ≥ 0; Log (PluriNet score) ≥ 3.0), and Group_3 (Log (T/R ratio) < 0; Log (PluriNet score) < 3.0). c Functional annotation of genes showing higher expression in Group_1 compared to Group_2. d Functional annotation of genes with higher expression in Group_1 compared to Group_3. e Violin plots detailing single cell telomere length distribution and expression of pluripotency genes in each telomere length (L long, M medium, S short) group. Y-axis indicates Log2 (TPM + 1)

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BMC Biology

ISSN: 1741-7007

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