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Fig. 1 | BMC Biology

Fig. 1

From: Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice

Fig. 1

The correlation between metabolite types and gut microbial phyla, and BA alterations with HFD intervention. a Principal component analysis was performed on each metabolite type and each phylum of gut microbiome. The t values of the first principal component (PC1) among the samples from control (n = 5) and HFD (n = 5) groups were selected as representative of each dataset. The heatmaps depict Spearman correlation of metabolite types and microbial phyla. Red and green cells indicate positive and negative correlations, respectively; *P < 0.05. b The concentrations of total, primary, and secondary BAs in caecal content in control (n = 7) and HFD (n = 7) groups. Data are expressed as mean ± SEM. Differences were assessed by the Mann–Whitney U test. Significance is established at adjusted P < 0.05 (*P < 0.05, **P < 0.01) with a false discovery rate (FDR) of 0.05. c The fold change ratios of the average concentrations of identified BA species in the HFD group (n = 7) to that in the control group (n = 7). Differences are assessed by the Mann–Whitney U test. Significance is established at adjusted P < 0.05 with FDR = 0.05

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