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Table 1 Gene ontology enrichment analysis of gene expression in response to P. rettgeri in entire flies

From: The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila

GO term

Description

P valuea

FDR q valueb

Enrichment (N, B, n, b)c

GO:0006952

defense response

4.09 × 10–8

4.71 × 10–5

2.70 (181, 38, 37, 21)

GO:0009617

response to bacterium

2.35 × 10–7

1.36 × 10–4

2.73 (181, 34, 37, 19)

GO:0043207

response to external biotic stimulus

1.18 × 10–6

4.52 × 10–4

2.45 (181, 40, 37, 20)

GO:0009607

response to biotic stimulus

1.18 × 10–6

3.39 × 10–4

2.45 (181, 40, 37, 20)

GO:0051707

response to other organisms

1.18 × 10–6

2.71 × 10–4

2.45 (181, 40, 37, 20)

GO:0051704

multi-organism process

2.03 × 10–6

3.91 × 10–4

2.39 (181, 41, 37, 20)

GO:0006955

immune response

2.29 × 10–6

3.77 × 10–4

2.68 (181, 31, 37, 17)

GO:0009605

response to external stimulus

5.7 × 10–6

8.22 × 10–4

2.28 (181, 43, 37, 20)

GO:0002376

immune system process

7.72 × 10–6

9.9 × 10–4

2.52 (181, 33, 37, 17)

GO:0006950

response to stress

1.56 × 10–5

1.8 × 10–3

2.10 (181, 49, 37, 21)

GO:0042742

defense response to bacterium

3.43 × 10–5

3.6 × 10–3

2.53 (181, 29, 37, 15)

GO:0050896

response to stimulus

5.73 × 10–5

5.51 × 10–3

1.81 (181, 65, 37, 24)

GO:0098542

defense response to other organisms

5.94 × 10–5

5.28 × 10–3

2.45 (181, 30, 37, 15)

GO:0050829

defense response to Gram-negative bacterium

2.8 × 10–4

2.31 × 10–2

2.88 (181, 17, 37, 10)

GO:0002682

regulation of immune system process

3.07 × 10–4

2.36 × 10–2

4.19 (181, 7, 37, 6)

GO:0050776

regulation of immune response

3.07 × 10–4

2.22 × 10–2

4.19 (181, 7, 37, 6)

GO:0031347

regulation of defense response

6.73 × 10–4

4.57 × 10–2

3.42 (181, 10, 37, 7)

GO:0019731

antibacterial humoral response

9.88 × 10–4

6.33 × 10–2

2.75 (181, 16, 37, 9)

  1. aThe enrichment P value computed according to the mHG or HG model. This P value is not corrected for multiple testing of 1636 GO terms
  2. bThe correction of the above P value for multiple testing using the Benjamini and Hochberg method
  3. cDefined as follows: N is the total number of genes, B is the total number of genes associated with a specific GO term, n is the number of genes in the top of the user’s input list or in the target set when appropriate, b is the number of genes in the intersection; enrichment = (b/n)/(B/N)