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Fig. 10 | BMC Biology

Fig. 10

From: Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala

Fig. 10

Influence of the overexpression of miR-105 on the expression of D1 receptors (D1R) in glutamatergic projection neurons from the mPFC to the BLA and the effect of the overexpression of miR-105 on CPA in morphine-withdrawal rats. a Top and bottom panels showed D1R staining (column 1, red color), eGFP labeling (column 2, green color), glutamatergic terminal marker VGLUT2 immunoreactivity (column 3, blue color), and coexpression of D1R, eGFP, and VGLUT2 (column 4, white color) in slices of the BLA in miR-105 NC-LV and miR-105-LV groups. The figure insets are the magnified views marked with small white rectangles. Scale bar, 5 μm. In higher magnification of areas in the insets the scale bar is 1 μm. b The average D1R expression intensity in glutamatergic projection neurons from the mPFC to the BLA in miR-105 NC-LV and miR-105-LV groups (n = 5, *P < 0.05, compared to miR-105 NC-LV group). c Effect of overexpression of miR-105 on CPA in morphine-withdrawal rats. n = 6, **P < 0.01, compared to preconditioning test in miR-105 NC-LV group. *P < 0.05, compared to preconditioning test in miR-105-LV group. # P < 0.05, compared to post-conditioning test in miR-105 NC-LV group. Data are shown as the mean ± SEM

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