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Fig. 8 | BMC Biology

Fig. 8

From: Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala

Fig. 8

Influence of chronic morphine on basic parameters of excitatory synaptic transmission between mPFC-to-BLA fibers and pyramidal cells of the BLA. a Effect of chronic morphine on PPF of light-evoked EPSCs between mPFC-to-BLA fibers and pyramidal cells of the BLA. Left panel: Representative traces of EPSCs induced by a paired-pulse optical stimulation in saline and chronic morphine groups. Right panel: Average PPF of EPSCs in saline and chronic morphine groups (n = 8, independent t test, P > 0.05, compared with saline group). b Effect of chronic morphine on AMPAR/NMDAR ratio between mPFC-to-BLA fibers and pyramidal cells of the BLA. Left panel: Representative traces of light-evoked AMPAR and NMDAR currents recorded from pyramidal cells of the BLA after optical stimulation of mPFC-to-BLA fibers in saline and chronic morphine groups. Right panel: Average AMPAR/NMDAR ratio in BLA neurons from mPFC-to-BLA fibers in saline and chronic morphine groups (n = 8, independent t test, *P < 0.05, compared to saline group). Data are shown as the mean ± SEM

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BMC Biology

ISSN: 1741-7007

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