Fig. 5
From: Systematic target function annotation of human transcription factors
The relationship between functional diversity and regulator diversity of transcription factors (TFs). a The target functions of TF HNF1A form three major clusters based on similarities (member gene sharing) among the functions, while the upstream regulators of HNF1A form clusters based on the functional similarities (target gene overlaps) among these regulators. The regulator and functional diversities of a gene measures the effective number of regulators and effective number of functions for a gene. The coloring schema is the same as in Fig. 3 and the clustering of TFs and functions are based on the TF’s target gene overlaps and the function’s member gene overlaps. b Significant associations exist between the regulator diversity and target function diversity of TFs for six types of function annotations separately