Skip to main content

Advertisement

Table 2 Discordance transcription factors’ target function similarity and target gene similarity

From: Systematic target function annotation of human transcription factors

TF pair classification Counts Significant sharing of known functionsc P value
Description Target-function sharing Target-gene sharing
Unexpected target function similarity Significanta Low 329 117 (35.6%) 0.0010 OR = 1.45
Other pairs with low target gene sharing Not Low 42,373 11,704 (27.6%)
Expected target function similarity Significanta Highb 4583 1772 (38.7%) 7.7 × 10-13 OR = 1.27
Other pairs with high target gene sharing Not Highb 26,251 8727 (33.2%)
  1. aSignificant target-function sharing: target function overlap significantly higher than expected by change (FDR ≤ 0.05)
  2. bHigh sharing of target gene: odds ratio of target gene sharing between a pair of TF is ≥ 1
  3. cSignificant sharing of known functions: known function overlap significantly higher than expected by change (FDR ≤ 0.01, see Additional file 1: Table S9 for results at threshold 0.05)
  4. OR odds ratio