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Table 2 Discordance transcription factors’ target function similarity and target gene similarity

From: Systematic target function annotation of human transcription factors

TF pair classification

Counts

Significant sharing of known functionsc

P value

Description

Target-function sharing

Target-gene sharing

Unexpected target function similarity

Significanta

Low

329

117 (35.6%)

0.0010 OR = 1.45

Other pairs with low target gene sharing

Not

Low

42,373

11,704 (27.6%)

Expected target function similarity

Significanta

Highb

4583

1772 (38.7%)

7.7 × 10-13 OR = 1.27

Other pairs with high target gene sharing

Not

Highb

26,251

8727 (33.2%)

  1. aSignificant target-function sharing: target function overlap significantly higher than expected by change (FDR ≤ 0.05)
  2. bHigh sharing of target gene: odds ratio of target gene sharing between a pair of TF is ≥ 1
  3. cSignificant sharing of known functions: known function overlap significantly higher than expected by change (FDR ≤ 0.01, see Additional file 1: Table S9 for results at threshold 0.05)
  4. OR odds ratio