Table 3 Functional pleiotropy and regulator diversity of selected transcription factors (TFs), including two most functional pleiotropic TFs, BRCA1 and ZNF143, two TFs with the highest upstream regulatory diversity, MYC and TP53, and three TFs with lower functional pleiotropy, HNF1A, NFKB1, and SUZ12
From: Systematic target function annotation of human transcription factors
TF | Function pleiotropy | Regulator diversity | ||||
|---|---|---|---|---|---|---|
Target function | Effective target function | Known function | Effective known function | Upstream regulator | Effective upstream regulator | |
BRCA1 | 272 | 45.5 | 101 | 14.5 | 33 | 15.9 |
ZNF143 | 242 | 35.4 | 22 | 2.8 | 53 | 22.1 |
MYC | 159 | 24.2 | 68 | 12.4 | 50 | 25.1 |
TP53 | 175 | 26.8 | 166 | 25.4 | 49 | 23.0 |
HNF1A | 30 | 6.3 | 58 | 11.2 | 9 | 3.8 |
NFKB1 | 143 | 23.7 | 34 | 6.2 | 26 | 11.7 |
SUZ12 | 48 | 8.3 | 4 | 1.0 | 11 | 4.9 |