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Table 3 Functional pleiotropy and regulator diversity of selected transcription factors (TFs), including two most functional pleiotropic TFs, BRCA1 and ZNF143, two TFs with the highest upstream regulatory diversity, MYC and TP53, and three TFs with lower functional pleiotropy, HNF1A, NFKB1, and SUZ12

From: Systematic target function annotation of human transcription factors

TF Function pleiotropy Regulator diversity
Target function Effective target function Known function Effective known function Upstream regulator Effective upstream regulator
BRCA1 272 45.5 101 14.5 33 15.9
ZNF143 242 35.4 22 2.8 53 22.1
MYC 159 24.2 68 12.4 50 25.1
TP53 175 26.8 166 25.4 49 23.0
HNF1A 30 6.3 58 11.2 9 3.8
NFKB1 143 23.7 34 6.2 26 11.7
SUZ12 48 8.3 4 1.0 11 4.9