TY - JOUR AU - Lerner, Thomas R. AU - Queval, Christophe J. AU - Fearns, Antony AU - Repnik, Urska AU - Griffiths, Gareth AU - Gutierrez, Maximiliano G. PY - 2018 DA - 2018/01/04 TI - Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells JO - BMC Biology SP - 1 VL - 16 IS - 1 AB - Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocytic cells, such as macrophages and dendritic cells, are the primary hosts for Mtb after infection and previous studies have shown multiple roles for PDIM in supporting Mtb in these cells. However, Mtb can infect other cell types. We previously showed that Mtb efficiently replicates in human lymphatic endothelial cells (hLECs) and that the hLEC cytosol acts as a reservoir for Mtb in humans. Here, we examined the role of PDIM in Mtb translocation to the cytosol in hLECs. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-017-0471-6 DO - 10.1186/s12915-017-0471-6 ID - Lerner2018 ER -