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Fig. 2 | BMC Biology

Fig. 2

From: A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer

Fig. 2

eNOS is significantly upregulated in human mesenchymal CRC tumors. a Unsupervised classification of the mesenchymal subgroup of CRC tumors and non-mesenchymal subtypes. The heat map was generated using nSolver software from NanoString Technologies. b eNOS expression as number of mRNA molecules detected. Te plots show normalized data of eNOS gene expression in all human CRC subtypes using the nCounter system from NanoString Technologies. c eNOS Western blot analysis of total protein extracts of classified human CRC tumors. *P < 0.05, **P < 0.01, ****P < 0.0001 compared with non-mesenchymal tumors. CRC: colorectal cancer, eNOS: endothelial NO synthase, iNOS: inducible NO synthase, CS-TA: colorectal subtype transit-amplifying

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