Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types

Table 2 Relative permeability of organoids as well as mRNA and protein expression of TJ proteins

Organoid Permeability		Cldn2		Cldn7		Ocln		ZO1		Cdh1
Organoid Permeability		mRNA	Protein	mRNA	Protein	mRNA	Protein	mRNA	Protein	mRNA	Protein
ISC	+	++++	++++	+	++	++++	++	+++	+++	+++	++++
ENT	++++	++	+	++++	++++	+++	+	+++	++	++	+++
GOB	++++	+	-	++	+++	+++	-	+++	++	++	++++
PAN	+	+++	++	+++	++++	++++	+++	++++	+	++++	++++

- = no expression, + = low, ++ = modest, +++ = high, ++++ = very high expression
Cldn claudin, ENT enterocyte, GOB goblet cell, ISC intestinal stem cell, PAN Paneth cell, TJ tight junction, ZO-1 tight junction protein-1

ISSN: 1741-7007