TY - JOUR AU - Schartl, Manfred AU - Schories, Susanne AU - Wakamatsu, Yuko AU - Nagao, Yusuke AU - Hashimoto, Hisashi AU - Bertin, ChloƩ AU - Mourot, Brigitte AU - Schmidt, Cornelia AU - Wilhelm, Dagmar AU - Centanin, Lazaro AU - Guiguen, Yann AU - Herpin, Amaury PY - 2018 DA - 2018/01/29 TI - Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements JO - BMC Biology SP - 16 VL - 16 IS - 1 AB - Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-functionalization, also requires the regulatory landscape to be rewired to accommodate these novel gene functions. We previously showed that in medaka fish, the regulatory landscape of the master male-determining gene dmrt1bY underwent a profound rearrangement, concomitantly with acquiring a dominant position within the sex-determining network. This rewiring was brought about by the exaptation of a transposable element (TE) called Izanagi, which is co-opted to act as a silencer to turn off the dmrt1bY gene after it performed its function in sex determination. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-018-0485-8 DO - 10.1186/s12915-018-0485-8 ID - Schartl2018 ER -