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Table 1 List of migration hits from siRNA library screen

From: An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

 

Impaired migration

Accelerated migration

HGF-dependent migration

Gene name

Accession number

Z-score

Gene name

Accession number

Z-score

Gene name

Accession number

Z-score

GTPases

RHOC

NM_175744

−1.2576

RAC3

NM_005052

1.6714

   

RHOH

NM_004310

−1.1161

RHOBTB1

NM_014836

1.2813

   

RHOV

NM_133639

−1.1100

RHOQ

NM_012249

1.1527

   

RhoGAPs

ARAP1

NM_015242

−1.3971

DLC1

NM_006094

1.2716

ARAP3 b

NM_022481

1.3769

SRGAP3

NM_014850

−1.3048

ARAP2

NM_015230

1.2509

ARHGAP24 b

NM_031305

1.1005

   

ARHGAP35

NM_024342

1.1569

SRGAP1 b

NM_020762

1.0760

   

ARHGAP4

NM_001666

1.0155

   

RhoGEFs

DOCK5

NM_024940

−2.3762

VAV1

NM_005428

1.6012

ARHGEF4 a

NM_015320

−1.6365

DOCK11

NM_144658

−1.7138

ARHGEF10

NM_014629

1.1390

ARHGEF19 a

NM_153213

−1.5797

DOCK6

NM_020812

−1.5419

PLEKHG6

NM_018173

1.1295

ARHGEF14 a

NM_024979

−1.2354

FGD2

NM_173558

−1.4725

ALS2

NM_020919

1.1294

FGD4 b

NM_139241

1.1248

DOCK3

NM_004947

−1.3736

PREX2

NM_024870

1.0269

   

ITSN2

NM_006277

−1.2293

RASGRF1

NM_002891

1.0074

   

SOS1

NM_005633

−1.1864

      

DOCK2

NM_004946

−1.1098

      

FGD5

NM_152536

−1.0918

      

Effectors

NOXA1

NM_006647

−1.4477

RHPN1

NM_052924

1.5692

CIT a

NM_007174

−1.0435

PIK3R2

NM_005027

−1.3197

TWF1

NM_002822

1.3241

CDC42EP b

NM_007061

1.4898

CDC42EP2

NM_006779

−1.2882

PAK4

NM_005884

1.2268

   

PKN3

NM_013355

−1.2045

PIK3R1

NM_181504

1.1572

   

PAK7

NM_020341

−1.0864

MLK4

NM_032435

1.0711

   

SMURF1

NM_020429

−1.0663

PLXNB1

NM_002673

1.0377

   

PAK2

NM_002577

−1.0318

      

Other

   

BCR

NM_004327

1.1558

RHOBTB3 a

NM_014899

−0.9751

  1. Hits are divided into Rho GTPases, RhoGEFs, RhoGAPs and effectors and subdivided into siRNA pools that impair or accelerate PC3 cell migration or affect only HGF-dependent migration; migration Z-score is indicated relative to the mean migration of all genes included in the screen. Accession number: RefSeq accession number is indicated
  2. HGF hepatocyte growth factor
  3. aHGF-impaired
  4. bHGF-accelerated