Fig. 3.From: Nothing in cancer makes sense except…Critical features of cancer clone phylogenetics. Left: Charles Darwin’s iconic ‘I think’ drawing of a phylogenetic tree from his 1837 Notebook (B) [85]. Right: Example of subclonal phylogeny based on single cell genetics (in leukemia), taken from author’s own research in [17]. Seven subclones shown (B2–8), each with mutations listed. B1 (7.1%) are normal cells. CDKN2A in green in box: reiterated mutation of same gene is different branches or subclones. One subclone (B3) is numerically dominant (at 54.9%)Back to article page