Fig. 5
From: Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
Effects of long-term ApN overexpression on NLRP3 and miR-711 levels in muscles of dystrophic mice. Three groups of mice were used: mdx mice overexpressing ApN, which were generated by transgenesis (mdx-ApN [9]), their mdx littermates (mdx) and WT mice. Nlrp3 mRNA (a) and protein (b) as well as miR-711 levels (c) were measured in tibialis anterior muscles, normalized to cyclophilin (a, c) or to actin (b), and the subsequent ratios were presented as relative expression compared to WT values. Results are means ± SEM for three to seven mice per group. #P < 0.05, ##P < 0.01, ###P < 0.001 vs WT; *P < 0.05, **P < 0.01 for mdx-ApN vs mdx mice