Fig. 6
From: Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

Effects of NLRP3 depletion on global force, resistance and muscle injury in mdx mice. Four groups of mice were used: mdx mice that were also deficient for Nlrp3 (mdx/Nlrp3-KO), regular mdx (mdx), Nlrp3-KO mice and WT ones. Several functional in vivo studies were carried out. a The animals were lowered on a grid connected to a sensor to measure the muscle force of both fore- and hindlimbs; data were then expressed in gram-force relative to body weight. b Mice were next subjected to a wire test where they were suspended by their forelimbs and the time until they completely released the wire and fell down was recorded. c Mice were also submitted to a downhill treadmill exercise for 10 min; the covered distance (metres) was measured for each mouse, 100 m being the maximal distance. d Muscle injury was assessed by plasma creatine kinase (CK) activity measured in the basal state and expressed as IU/L. Results are means ± SEM for eight to twelve mice per group. ##P < 0.01, ###P < 0.001 vs WT; *P < 0.05, **P < 0.01 for the indicated conditions