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Fig. 1 | BMC Biology

Fig. 1

From: Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins

Fig. 1

A cartoon depicting the architecture of the type I-F CRISPR-Cas system and inhibition mechanisms of three type I-F anti-CRISPRs. a The type I-F Csy complex is a 350-kDa crRNA-guided surveillance complex composed of a 60-nucleotide crRNA and nine Cas proteins, which recruits a nuclease-helicase protein Cas3 for target degradation. b AcrF1 interacts with Cas7f, sterically hindering target DNA access to the crRNA guide. c AcrF2 interacts with Cas8f and Cas7f, resembling a DNA duplex and sterically hindering target dsDNA access to the binding pocket. d AcrF3 forms a homodimer, interacting with Cas3 and impeding the recruitment of Cas3 to Cascade

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