Fig. 6.
From: Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
Cartoon and topological views of the structures of type II anti-CRISPR proteins. a Structure of the AcrIIA4–SpyCas9–sgRNA complex. SpyCas9 and AcrIIA4 are colored magenta and cyan, respectively. The crRNA is colored blue. The RuvC, CTD, and TOPO domains of SpyCas9 are labeled. b Topological view of AcrIIA4. c Structure of the AcrIIC1–HNHNmeCas9 domain complex. AcrIIC1 and the HNHNmeCas9 domain are colored cyan and orange, respectively. d Topological view of AcrIIC1. e Structure of the AcrIIA1 dimer. The AcrIIA1 dimer is colored cyan and green. f Topological view of AcrIIA1