Skip to main content
Fig. 7 | BMC Biology

Fig. 7

From: Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Fig. 7

REDD1 controls stress-induced reduction in O2 consumption and anabolic processes. In the basal state, activation of the Akt/mTOR pathway promotes (i) anabolic processes (protein and glycogen synthesis), (ii) the mitochondria/ER interaction, and (iii) oxygen-dependent ATP production. In response to energetic stress, REDD1 inhibits the Akt/mTOR pathway and interacts with MAMs, leading to a coordinated decrease in MAMs extent, mitochondrial oxygen consumption, and anabolic processes. This mechanism could contribute to spare ATP in stressful conditions

Back to article page