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Fig. 3 | BMC Biology

Fig. 3

From: Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

Fig. 3

YAC128 MSNs in 1:1 CS co-culture demonstrate reduced dendritic length and complexity. WT and YAC128 co-cultures were generated at either a 1:1 or 1:3 CS ratio and processed at DIV21 for DARPP32 immunocytochemistry, imaging, and dendritic analysis. (a) Sample images of MSN dendritic traces generated in NeuronStudio (scale bar = 15 μm). (Bi) Total length of the dendritic trace and (Bii) complexity by Sholl analysis are significantly reduced in 1:1 YAC128 MSNs compared to WT. Post-hoc statistical significance for Sholl analysis is shown only for WT 1:1 vs. YAC128 1:1 (*) or WT 1:3 vs. YAC128 1:3 (#) comparisons [n = 32(4); two-way ANOVA with Bonferroni post-hoc analysis; *p < 0.05, **p < 0.01, ***p < 0.001]

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BMC Biology

ISSN: 1741-7007

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