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Fig. 2 | BMC Biology

Fig. 2

From: Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir

Fig. 2

a Histogram of predicted activity of all gRNAs identified in LTR, gag, and pol across all four consensus sequences (group M, subtypes A–C) for each gene. b Predicted activity score vs. target site conservation for individual gRNAs grouped by subtype and gene. Red triangles indicate gRNAs excluded due to predicted off-target activity. Numbers in blue represent the total number of guides with predicted activity score > 0.2 and where target sites occur in more than 50% of sequences in the group or subtype alignment

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