Fig. 2From: Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoira Histogram of predicted activity of all gRNAs identified in LTR, gag, and pol across all four consensus sequences (group M, subtypes A–C) for each gene. b Predicted activity score vs. target site conservation for individual gRNAs grouped by subtype and gene. Red triangles indicate gRNAs excluded due to predicted off-target activity. Numbers in blue represent the total number of guides with predicted activity score > 0.2 and where target sites occur in more than 50% of sequences in the group or subtype alignmentBack to article page