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Fig. 3 | BMC Biology

Fig. 3

From: Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

Fig. 3

The impact of aging on the NMR liver proteome. a Livers from three young (2.7–3.8 years old) and three old (> 18 years old) NMRs were compared by Tandem Mass Tags (TMT)-based quantitative mass spectrometry. Hierarchical clustering based on the correlation between proteome profiles based on 5237 protein groups cross-quantified between the two age groups (Additional file 5: Table S4). b Gene set enrichment analysis. Gene sets are plotted according to the log10 value of the calculated enrichment score. Positive and negative values are used for gene sets showing higher and lower abundance in old NMRs, respectively. Selected significantly affected gene sets (q < 0.05) are highlighted. The complete list of enriched gene sets is available in Additional file 7: Table S5. c Overlap between proteins differentially expressed in NMR vs. GP and affected by aging in NMR. d Comparison between cross-species and aging-related fold changes for the 99 proteins significantly different in both comparisons. e Cumulative distributions of significant NMR vs. GP fold differences for the 99 proteins also significantly upregulated (red) or downregulated (blue) in aging. f The 62 proteins with significant but opposite fold changes in both comparisons (Additional file 8: Table S6). Proteins involved in lipid/fatty acid metabolism and xenobiotic metabolism are highlighted in green and orange, respectively. Related to Additional file 5: Table S4, Additional file 6: Figure S2, Additional file 7: Table S5, and Additional file 8: Table S6

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