TY - JOUR AU - Berthenet, Elvire AU - Yahara, Koji AU - Thorell, Kaisa AU - Pascoe, Ben AU - Meric, Guillaume AU - Mikhail, Jane M. AU - Engstrand, Lars AU - Enroth, Helena AU - Burette, Alain AU - Megraud, Francis AU - Varon, Christine AU - Atherton, John C. AU - Smith, Sinead AU - Wilkinson, Thomas S. AU - Hitchings, Matthew D. AU - Falush, Daniel AU - Sheppard, Samuel K. PY - 2018 DA - 2018/08/02 TI - A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk JO - BMC Biology SP - 84 VL - 16 IS - 1 AB - Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gastric cancer. Epidemiological evidence shows that progression to cancer depends upon the host and pathogen factors, but questions remain about why cancer phenotypes develop in a minority of infected people. Here, we use comparative genomics approaches to understand how genetic variation amongst bacterial strains influences disease progression. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-018-0550-3 DO - 10.1186/s12915-018-0550-3 ID - Berthenet2018 ER -