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Fig. 7 | BMC Biology

Fig. 7

From: Additive contributions of melanopsin and both cone types provide broadband sensitivity to mouse pupil control

Fig. 7

Contributions of melanopsin to pretectal neuronal responses. a, c Mean ± SEM responses of Opn1mwR MR units (a; n = 50) and Opn1mwR; Opn4−/− cells (c; n = 23) to rapid (0.25 Hz square wave; left) or gradual (0.025 Hz sinusoid; right) spectrally neutral stimulus modulations (all opsins) and stimuli targeting just L- and S-cone opsin (75% contrast). b, d Contrast (left) and temporal frequency (right) tuning curves for Opn1mwR MR (b) and Opn1mwR; Opn4−/− (d) responses to all opsin and L + S-opsin-isolating stimuli (as above). For contrast response analysis, data points represent difference in mean firing rate during the last 400 ms at ‘bright’ vs. ‘dim’ stimulus phases. For temporal frequency analysis, data points represent the % variance in firing rate accounted for the stimulus. In both cases, data analysed by two-way RM ANOVA with Sidak’s post-tests. *** = P < 0.001

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