Fig. 1

Number and size distributions of fill sizes of whole-genome alignments between human and 12 other species. a Phylogenetic tree with estimated divergence times according to http://timetree.org/ b Number of syntenic alignment blocks (fills) between human (hg38) and 12 other species. Top-level fills are the largest and highest scoring chains and occur at the top level in the hierarchy in net files (top panel). Non-syn fills map to different chromosomes as their parent fills in the net files (bottom panel). c Size distribution of top-level (top panel) and non-syntenic (bottom panel) fills as violin plot. d Number of identified rearrangement breakpoints between human and 12 other species. Breakpoints are borders of top-level or non-syn fills that are larger or equal than a given size threshold (x-axis)