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Table 3 Binding affinities and kinetic rate constants for binding of Ang2-BD BC5 to immobilized integrins

From: Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

Integrin KD ± sem, nM Kon1 ± sem (M−1 s−1) × 104 Koff1 ± sem (s−1) × 10−3 Kon2 ± sem (s−1) × 10−3 Koff2 ± sem (s−1) × 10−3
αvβ1 550 ± 90.1 1.14 ± 0.01 6.29 ± 0.17 3.04 ± 0.12 1.97 ± 0.03
αvβ5 65 ± 21.8 3.98 ± 0.03 2.59 ± 0.12 5.44 ± 0.21 0.35 ± 0.01
αvβ6 364 ± 70.8 2.29 ± 0.05 8.35 ± 0.45 3.2 ± 0.17 1.06 ± 0.03
αvβ8 138 ± 50.3 3.66 ± 0.03 5.05 ± 0.13 2.4 ± 0.12 2.15 ± 0.05
  1. Values in the table are means ± SEM. SPR sensorgram curves were fit to a two-state binding model