TY - JOUR AU - Xiong, Chaoyang AU - Wen, Zengqi AU - Yu, Juan AU - Chen, Jun AU - Liu, Chao-Pei AU - Zhang, Xiaodong AU - Chen, Ping AU - Xu, Rui-Ming AU - Li, Guohong PY - 2018 DA - 2018/10/03 TI - UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells JO - BMC Biology SP - 110 VL - 16 IS - 1 AB - H3.3 is an ancient and conserved H3 variant and plays essential roles in transcriptional regulation. HIRA complex, which is composed of HIRA, UBN1 or UBN2, and Cabin1, is a H3.3 specific chaperone complex. However, it still remains largely uncharacterized how HIRA complex specifically recognizes and deposits H3.3 to the chromatin, such as promoters and enhancers. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-018-0573-9 DO - 10.1186/s12915-018-0573-9 ID - Xiong2018 ER -