TY - JOUR AU - van Dijk, Juliette AU - Bompard, Guillaume AU - Cau, Julien AU - Kunishima, Shinji AU - Rabeharivelo, Gabriel AU - Mateos-Langerak, Julio AU - Cazevieille, Chantal AU - Cavelier, Patricia AU - Boizet-Bonhoure, Brigitte AU - Delsert, Claude AU - Morin, Nathalie PY - 2018 DA - 2018/10/18 TI - Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation JO - BMC Biology SP - 116 VL - 16 IS - 1 AB - Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimately released. Microtubule dynamics, bundling, sliding, and coiling, drive these dramatic morphological changes whose regulation remains poorly understood. Microtubule properties are defined by tubulin isotype composition and post-translational modification patterns. It remains unknown whether microtubule post-translational modifications occur in proplatelets and if so, whether they contribute to platelet formation. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-018-0584-6 DO - 10.1186/s12915-018-0584-6 ID - van Dijk2018 ER -