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Fig. 4 | BMC Biology

Fig. 4

From: Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Fig. 4

Loss of atfs-1 alters physiologic rates in the nuo-6 mitochondrial mutant. a nuo-6 worms have increased embryonic lethality compared to wild-type worms, and lethality is further increased by deletion of atfs-1. b While all nuo-6 worms develop to adulthood after hatching, a proportion of nuo-6;atfs-1 worms arrest during larval development. c Deletion of atfs-1 slows development in wild-type worms but accelerates development time in nuo-6 worms. d Loss of atfs-1 decreases brood size in wild-type worms but does not further decrease the low brood size in nuo-6 worms. e The atfs-1 deletion decreases the rate of movement in wild-type worms but does not exacerbate the slow movement of nuo-6 worms. Loss of atfs-1 causes a slow rate of defecation (f) decreased body length (g), and decreased oxygen consumption (h) in both wild-type and nuo-6 worms, but does not significantly affect ATP levels (i). Error bars indicate SEM. *p < 0.05,**p < 0.01, ***p < 0.001. See Additional file 5: Table S5 for details on N and replicates

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