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Fig. 8 | BMC Biology

Fig. 8

From: Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Fig. 8

Gene expression changes in gain-of-function atfs-1 mutants exhibit significant overlap with daf-2 mutants and enrichment of DAF-16 target genes. a Venn diagrams indicate the overlap in differentially expressed genes between the two atfs-1 gain-of-function mutants (et15 and et17) and daf-2(e1370). The changes in gene expression in atfs-1(et17) almost completely overlap with those in atfs-1(et-15). Percentages indicate the percent of all of the genes that are differentially expressed in one of the three mutants. b Heat maps showing the expression of DAF-16 target genes in atfs-1 gain-of-function mutants compared to daf-2. The genes shown are the top DAF-16 target genes determined by a meta-analysis of gene expression data performed by Tepper et al., 2013. Only genes that showed a significant change in expression in daf-2 mutants are shown. The atfs-1 gain-of-function mutants show upregulation of many of the top DAF-16 upregulated genes and downregulation of many of the top DAF-16 downregulated genes. However, some genes show the opposite pattern of regulation

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BMC Biology

ISSN: 1741-7007

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