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Fig. 11 | BMC Biology

Fig. 11

From: Circadian oscillator proteins across the kingdoms of life: structural aspects

Fig. 11

Structure of Rev-erb β LBD monomer. a The apo form (green), without heme (PDB 2V0V), and b as a heme-containing (yellow) complex (PDB 3CQV), with the prosthetic group bound in the ligand-binding pocket. The conserved Cys384 (cyan) and His568 (red) residues involved in heme-binding are shown in stick representation. Helices H11 (red) and H3 undergo conformational changes to accommodate the heme prosthetic group. c The domain architecture of the Rev-erbs depicting the variable N-terminal A/B region (orange), DNA-binding domain (DBD) and the ligand-binding domain (LBD)

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