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Table 3 Drug susceptibility of mycobacterial strains transformed with Rv00171/74-9 m

From: A deletion in the RD105 region confers resistance to multiple drugs in Mycobacterium tuberculosis

Strain

MIC (μg/mL)

SM

RFP

INH

EMB

OFX

AMK

CFZM

CFXS

LZD

M. smegmatis + pVV16

1

16

> 8

≤ 0.25

0.5

1

4

1

0.125

M. smegmatis + pVV16::3 m

1

16

> 8

≤ 0.25

0.5

0.5

4

1

0.125

M. smegmatis + pVV16::9 m

> 32

> 32

> 8

> 32

4

> 32

> 8

> 64

2

M. marinum + pVV16

8

0.5

4

2

4

1

2

8

1

M. marinum + pVV16::3 m

8

0.5

4

2

4

1

2

8

1

M. marinum + pVV16::9 m

> 32

4

> 8

16

32

4

8

64

4

H37Ra + pVV16

4

< 0.25

0.125

0.5

0.5

2

2

8

1

H37Ra + pVV16::3 m

4

< 0.25

0.25

0.5

0.5

2

1

16

1

H37Ra + pVV16::9 m

32

1

1

4

4

8

8

> 64

4

  1. SM streptomycin, RFP rifampicin, INH isoniazid, EMB ethambutol, OFX ofloxacin, AMK amikacin, CFZM ceftazidime, CFXS cefoxitin sodium, LZD linezolid