Fig. 5

Protein structures of the presumptive locally translated proteome. a SCOP folds enriched in the locally translated proteins compared to the neuron-expressed proteins as a whole. The number of predicted domains in the local proteome for each fold is shown to the right of the bar. b Two-dimensional representation of the protein structure space occupied by neuronally expressed protein domains. All neuronally expressed protein domains are shown in gray in the background, and locally translated protein domains are shown in the forefront colored by predicted fold (note that multiple folds may have similar colors due to the large number of folds). Locally translated proteins cover most of the structure space spanned by the whole-neuron set. Projection generated by t-Distributed Stochastic Neighbor Embedding (tSNE) of the PESS coordinates of each input domain