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Fig. 2. | BMC Biology

Fig. 2.

From: Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors

Fig. 2.

Death domain and TIR assemblies in Toll signalling through the myddosome. a An activated dimeric Toll-like receptor 4 (TLR4) showing the arrangement of its cytosolic TIR domains in association with Myd88 TIR domains, MyD88 death domains (DD), and interleukin-1 receptor-associated kinase (IRAK) kinase domains (KIN). b The myddosome DD assembly is shown with six MYD88 DDs (blues and green), four IRAK4 DDs (red, orange and yellow) and four IRAK2 DDs (violet). Image and legend adapted from [1]

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