Fig. 1
From: Cell size sensing—a one-dimensional solution for a three-dimensional problem?
Different models for cell size regulation. a The adder model enables size homeostasis without active size sensing. If large and small cells add a constant amount of cell mass in each division cycle, size variations will be reduced over multiple divisions to reach a uniform cell size in the population. b The sizer model postulates active size sensing, ensuring that cell division occurs only upon reaching a constant overall cell mass, hence maintaining size homeostasis in each cell cycle. c Post-mitotic cells such as neurons grow to characteristic size ranges after birth, without any subsequent cell division; hence, their growth must be constrained by sizer-like mechanisms or by extrinsic factors