Fig. 3From: The emergence of the two cell fates and their associated switching for a negative auto-regulating geneThe Fano factor curves and the probability of inhibition curves of the self-repressing gene circuit. a Dose-response of the Fano factor (F = σ2/μ) of the TetR-Venus expression for the self-repressing gene circuit (MG::PR-8 T) at different inducer concentrations. The Fano factor is defined as σ2/μ, where σ2 and μ are the variance and the mean of the probability distribution. b The probability of inhibition curves of the MG::PR-8 T circuit at different inducer concentrations. Seven color histograms represent different inducer concentrations. The inhibition curves were obtained by the ratio of the cells with a fluorescence intensity lower than a certain value to the number of the total samples. c The probability distribution of the TetR proteins for the circuit of MG::PR-8 T with different concentrations of inducers from the stochastic simulation model. P(n) (z axis) represents the probability distribution of the TetR protein numbers (x axis), n at different numbers of inducer (aTc) molecules (y axis). d The probability of inhibition curves of the model. The cumulative distribution functions of the simulation were obtained from Fig. 3c. Seven color histograms represent different inducer concentrationsBack to article page