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Fig. 3 | BMC Biology

Fig. 3

From: The emergence of the two cell fates and their associated switching for a negative auto-regulating gene

Fig. 3

The Fano factor curves and the probability of inhibition curves of the self-repressing gene circuit. a Dose-response of the Fano factor (F = σ2) of the TetR-Venus expression for the self-repressing gene circuit (MG::PR-8 T) at different inducer concentrations. The Fano factor is defined as σ2, where σ2 and μ are the variance and the mean of the probability distribution. b The probability of inhibition curves of the MG::PR-8 T circuit at different inducer concentrations. Seven color histograms represent different inducer concentrations. The inhibition curves were obtained by the ratio of the cells with a fluorescence intensity lower than a certain value to the number of the total samples. c The probability distribution of the TetR proteins for the circuit of MG::PR-8 T with different concentrations of inducers from the stochastic simulation model. P(n) (z axis) represents the probability distribution of the TetR protein numbers (x axis), n at different numbers of inducer (aTc) molecules (y axis). d The probability of inhibition curves of the model. The cumulative distribution functions of the simulation were obtained from Fig. 3c. Seven color histograms represent different inducer concentrations

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