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Table 2 I-TASSER GO/functional predictions for unclassified, rapamycin-induced genes that regulate development (see Fig. 7b, Table 1)

From: mTORC1/AMPK responses define a core gene set for developmental cell fate switching

Gene ID and protein size

Biological function

Molecular function

Cellular component

Ligand binding and homology domains

DDB_G0292188

750 amino acids

GO:0007166

Cell surface receptor signaling pathway

GO:0004888

Transmembrane signaling receptor activity

GO:0016021

Integral component of membrane

Glutamic acid; zinc

von Willebrand factor (vWF) type A domain

DDB_G0267942

898 amino acids

GO:0033365

Protein localization to organelle

GO:0005515

Protein binding

GO:0031967

Organelle envelope

Zinc

Gram domain

DDB_G0281781

620 amino acids

GO:0016477

Cell migration

GO:0004872

Signaling receptor activity

GO:0005924

Cell-substrate adherens junction

Glucose; calcium

(None)

DDB_G0269670

568 amino acids

GO:0007018

Microtubule-based movement

GO:0032559

Adenyl ribonucleotide binding

GO:0030286

Dynein complex

Zinc; magnesium; iron

C2 and WW domains

DDB_G0280921

1049 amino acids

GO:0030032

Lamellipodium assembly

GO:0005515

Protein binding

GO:0044424

Intracellular part

Zinc; magnesium; calcium

Phox homology domain

  1. Annotated protein sequences [46, 47] of characterized early Rapamycin upregulated genes (see Fig. 7b, Table 1) were analyzed by I-Tasser [48, 49]