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Fig. 3 | BMC Biology

Fig. 3

From: RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting

Fig. 3

PXDC1 and ADAM23 are incompletely imprinted genes that lie adjacent to known imprinted genes. ae PXDC1 lies ~ 100 kb distal to the known paternally expressed gene FAM50B at 6p25.2 and, although biallelically expressed, shows approximately 2-fold higher expression from the paternal allele in both LCLs (b, d) and WB (c, e). fj ADAM23 lies ~ 130 kb distal to the known paternally expressed gene ZDBF2 at 2q33.3 and also exhibits ~ 2-fold over-expression from the paternal allele in LCLs (g, i) and WB (h, j). a, f The mean fraction of reads transcribed from the paternal allele at every informative SNV position (the Pat ratio) is shown as bar, using a baseline of 0.5 (corresponding to equal expression of the two parental alleles). SNVs with preferential paternal expression (Pat ratio > 0.5) are shown in blue, while SNVs with preferential maternal expression (Pat ratio < 0.5) are shown in red. d/e, i/j Vectors join the allelic expression values within each informative individual based on the sum of total RNA-Seq reads overlapping phased heterozygous SNVs within each gene

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