Fig. 3

Process of identifying TFs regulating phenotypic variation. A hypergeometric test is used to test the overlap between a TF’s “binding change SNPs,” based on presence within ChIP peaks from ENCODE and high Delta-MOP score, and “phenotype-associated SNPs,” i.e., eQTLs of genes whose expression correlates with phenotype, located within cis-regulatory regions of the gene identified by Hi-C data. A TF is considered significant to the phenotype if the FDR q value is below 0.05