Fig. 4

Predicted mechanisms of ELF1 regulation of doxorubicin-induced apoptosis. Black solid arrows show the skeleton of two major pathways to doxorubicin-induced apoptosis, viz., those mediated by DNA damage and reactive oxygen species (ROS) respectively. Genes directly involved in these pathways are shown as ovals placed on the arrows. Green ovals represent drug response-associated genes that are predicted to be regulated by ELF1 and have been previously shown to have regulatory function on a pathway gene. Such regulatory evidence, presented in previous literature, is represented by gray dashed arrows connecting ELF1-regulated DRGs to pathway genes