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Fig. 6 | BMC Biology

Fig. 6

From: FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation

Fig. 6

A proposed model for the role of FoxH1 in the regulation of miR-430 activity. a Wild-type FoxH1 causes chromatin looping, preventing expression of miR-430. In MZsur mutants lacking the FHD, this loop is absent because FoxH1 binds only to the miR-430 cluster. If FoxH1 lacking a functional SID or FHD (due to mutation (m786) or replacement (VP16/GFP/EN)) is injected into wild types, higher expression of miR-430 occurs due to loss of looping and inhibitory regulation. b FoxH1 occupies non-canonical (NC) target sequences at miR-430 loci to induce chromatin scaffolding and prevent pri-miR-430 expression. With the onset of gastrulation, FoxH1 leaves the site, allowing miR-430 to become active and repress its targets (T1/T2)

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