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Table 1 Examples of potential therapeutics expressed in CFS to date

From: Synthetic Biology Goes Cell-Free

Therapeutic proteins Granulocyte macrophage colony-stimulating factor (GM-CSF) [68, 70]
Erythropoietin [70,71,72]
Cytotoxic protein onconase [73]
Antibodies [51, 74, 75] and antibody fragments [49, 76,77,78,79]
Bispecific antibodies [80]
Antibody-drug conjugates [49, 81]
Tissue-type plasminogen activator [82,83,84,85]
Vaccine antigens Picornaviral capsid intermediate structures [86]
Trimeric influenza hemagglutinin head [87] and stem [88] proteins
Trivalent vaccine based on Hc fragments of botulinum toxins A, B, and E [89]
Anthrax protective antigen and diphtheria toxoid [49]
Virus-like particles A B-cell lymphoma vaccine [90]
Anti-hepatitis B VLPs [91]
A virus-like nanoparticle scaffold for vaccines and drug delivery [92]
Antimicrobials Antimicrobial peptides [49, 93]
Small molecules such as violacein [49, 56]
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